High spindle and kinetochore-associated complex subunit-3 expression predicts poor prognosis and correlates with adverse immune infiltration in hepatocellular carcinoma

Figure 1 Spindle and kinetochore-associated complex subunit 3 expression levels in cancers. A: Expression levels of spindle and kinetochore-associated complex subunit 3 (SKA3) in different cancers according to the Tumor Immune Estimation Resource database; B and C: Expression levels of SKA3 in hepatocellular carcinoma (HCC) tissues and normal tissues in The Cancer Genome Atlas database; B: Unmatched tissues; C: Matched tissues; D-G: Validation of high SKA3 expression in HCC using an external database and clinical specimens; D and E: GSE62232 and GSE121248 datasets; F: Western blot; G: The relative expression of SKA3 protein was analyzed by ImageJ software. SKA3: Spindle and kinetochore-associated complex subunit 3; HCC: Hepatocellular carcinoma. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001.