Comparison between upfront surgery and neoadjuvant chemotherapy in patients with locally advanced gastric cancer: A systematic review

Table 2 Patient demographics and clinical characteristics

Ref.	Study population	Sex	Age (yr)	EGJ involvement	Staging
Ahn et al[8], 2014	140	101 males, 39 females	NAT, 53.8; US, 58.9	NS	T0, n = 2
					T1, n = 35
					T2, n = 40
					T3, n = 31
					T4, n = 28
					Unknown, n = 4
Biondi et al[9], 2018	417	262 males, 155 females	NAT, 58 ± 10; US, 55 ± 13	n = 26	0, n = 1
					I, n = 101
					II, n = 87
					III, n = 169
					IV, n = 59
Bracale et al[10], 2021	194	119 males, 75 females	NAT, 69.4; US, 70.5	None	II, n = 48
					III, n = 146
Eom et al[11], 2018	129	90 males, 39 females	NAT, 53; US, 57	None	IIIA, n = 61
					IIIB, n = 57
					IV, n = 11
Feng et al[12], 2015	170	134 males, 36 females	60 (21-82)	NS	T1, n = 5
					T2, n = 17
					T3, n = 29
					T4, n = 119
Wang et al[13], 2021	60	32 males, 28 females	32-70	NS	T3, n = 32
					T4a, n = 28
Xue et al[14], 2018	100	76 males, 24 females	69 patients < 65 yr	NS	T2, n = 10
					T3, n = 31
					T4a, n = 58
					T4b, n = 1
Kang et al[15], 2021	484	384 males, 100 females	58 (20-75)	NS	T2, n = 25
					T3, n = 116
					T4a, n = 305
					T4b, n = 38
Kano et al[16], 2019	76	61 males, 15 females	NAT, 69.3 ± 7.76; US, 70.4 ± 8.5	None	IIB, n = 27
					IIIA-C, n = 49
Lin et al[17], 2022	462	349 males, 113 females	NAT, 58; AT, 61	NS	T0, n = 10
					T1, n = 18
					T2, n = 65
					T3, n = 101
					T4, n = 158
Marino et al[18], 2021	177	107 males, 70 females	73.3 ± 10.4	NS	T2, n = 4
					T3, n = 27
					T4, n = 16
Molina et al[19], 2013	40 (39 surgery)	29 males, 11 females	64.3 (39.1-82.2)	NS	II, n = 21
					III, n = 19
Pardo et al[20], 2020	814	513 males, 295 females	351 patients < 70; 399 patients > 70	NS	T1, n = 6
					T2, n = 210
					T3, n = 375
					T4a, n = 164
					T4b, n = 31
Wang et al[21], 2019	82	65 males, 17 females	NAT, 23 patients < 60, 18 patients > 60; US, 24 patients < 60, 17 patients > 60	None	II, n = 22
					III, n = 60
Wang et al[22], 2021	778	580 males, 198 females	NAT, 56.13; US, 55.94	None	II, n = 132
					III, n = 646
Wu et al[23], 2019	172	139 males, 33 females	NAT, 54.83; US, 54.98	NS	II, n = 10
					III, n = 162
Xu et al[24], 2021	442	331 males, 114 females	NAT, 63; US, 61	NS	T4, n = 442
Zhao et al[25], 2017	102	82 males, 20 females	59 (34-77)	NS	IIB, n = 23
					IIIA, n = 39
					IIIB/C, n = 40

EGJ: Esophagogastric Junction; NAT: Neoadjuvant chemotherapy; US: Upfront surgery; NS: Not stated.