Radiation therapy prior to a pancreaticoduodenectomy for adenocarcinoma is associated with longer operative times and higher blood loss

Table 4 Odds ratios for 30-day postoperative complications for patients with adenocarcinoma of the pancreas undergoing a pancreaticoduodenectomy from 2015 to 2019

Complication	Neoadjuvant radiotherapy crude OR (95%CI)	Crude P value	Neoadjuvant radiotherapy adjusted OR/IRR (95%CI)	Adjusted P value
Total operative time	0.15 (0.13, 0.16)	< 0.001a	1.14 (1.11,1.16)1	< 0.001a
Perioperative transfusion	1.49 (1.32, 1.69)	< 0.001a	1.58 (1.37, 1.82)2	< 0.001a
Superficial SSI	1.13 (0.93, 1.38)	0.217	NP	NP
Organ space SSI	0.76 (0.63, 0.91)	0.004a	0.80 (0.66, 0.97)3	0.020a
30-d reoperation	1.03 (0.80, 1.32)	0.832	NP	NP
30-d mortality rate	0.40 (0.21, 0.75)	0.005a	NP	NP
30-d readmission rate	1.14 (0.98, 1.32)	0.090	NP	NP
Renal failure	0.74 (0.37, 1.47)	0.382	NP	NP
Total hospital stay	0.09 (0.06, 0.12)	< 0.001a	0.99 (0.96, 1.02)4	0.640
Drain in place on POD 30	0.76 (0.61, 0.99)	0.041a	0.82 (0.64, 1.06)5	0.124
Pancreatic fistula	0.47 (0.38, 0.58)	< 0.001a	0.50 (0.40, 0.63)5	< 0.001a
Delayed gastric emptying	0.81 (0.69, 0.95)	0.010a	0.86 (0.72, 1.01)5	0.073

^aP < 0.05.

¹Odds ratio was adjusted for: Albumin, age, sex, race, body mass index (BMI), diabetes, dyspnea, chronic obstructive pulmonary disease (COPD), hypertension, elective surgery, wound class, biliary stent, pancreatic duct size, perioperative transfusion requirement, surgical approach, resection of artery or vein.

²Odds ratio was adjusted for: Albumin, age, sex, race, BMI, diabetes, dyspnea, COPD, hypertension, elective surgery, wound class, biliary stent, surgical approach, resection of artery or vein, T-stage, N-stage.

³Odds ratio was adjusted for: Age, race, BMI, diabetes, steroids, wound class, American society of anesthesiologists (ASA) class, surgical approach, resection of artery or vein.

⁴Odds ratio was adjusted for: Age, race, BMI, diabetes, steroids, wound class, ASA class, surgical approach, resection of artery or vein, organ space infection, failure to wean off ventilator by post-operative day (POD) 30, drain in place by POD 30, return to the odds ratio within 30 d of index operation, delayed gastric emptying, T-stage, N-stage, M-stage.

⁵Odds ratio was adjusted for: Age, race, BMI, diabetes, steroids, wound class, ASA class, surgical approach, resection of artery or vein.

IRR: Insulin receptor-related receptor; NP: Not performed; OR: Odds ratio; POD: Post-operative day; SSI: Surgical site infection.