Differences in metabolic improvement after metabolic surgery are linked to the gut microbiota in non-obese diabetic rats

Figure 3 Postoperative improvement in glucose metabolism in rats. A: Oral glucose tolerance test (OGTT) in rats at 0 wk; B: OGTT in rats at 6 wk postoperatively; C: Area under the curve of OGTT; D: Insulin sensitivity test (ITT) in rats at 0 wk; E: ITT in rats at 6 wk postoperatively; F: Area under the ITT curve. Data are presented as mean ± SEM. Statistical significance was determined by two-tailed Student’s t-test or two-way analysis of variance, sleeve gastrectomy (SG) vs sham P value magnitude, ^aP < 0.05, ^bP < 0.01, ^cP < 0.001; distal small bowel bypass (DSIB) vs sham group P value magnitude, & DSIB vs SG P value magnitude, ^dP < 0.05, ^eP < 0.01, ^fP < 0.001. AUC: Area under the curve; ITT: Insulin tolerance test; OGTT: Oral glucose tolerance test.