Resection of isolated liver oligometastatic disease in pancreatic ductal adenocarcinoma: Is there a survival benefit? A systematic review

Table 5 Metachronous isolated liver metastases resection outcomes vs controls

Ref.		Treatment modality	n of patients	Median age	n of mets	Max met diameter	Overall survival1 (median, months)	P value
Dünschede et al[23], 2010	Control	Systemic chemotherapy (gemcitabine), no surgery	5	42	1.75	2.2 cm (average)	11 (8-19)	< 0.05
	Intervention	Resection of liver metastases	4	42	1.75	2.2 cm (average)	31 (20-51)
Schwarz et al[26], 2020	Control	Systemic chemotherapy (gemcitabine), no surgery	8	Median 69.4	2	-	9.2	0.0007
	Intervention	Resection of liver metastases	25	Median 63.8	1	-	36.8

¹All median overall survival values are from liver metastases resection except Dünschede et al[23]. Which is reported from time of diagnosis.