Resection of isolated liver oligometastatic disease in pancreatic ductal adenocarcinoma: Is there a survival benefit? A systematic review

Table 4 Metachronous isolated liver metastases resection outcomes

Ref.	n of patients	Age (median IQR)	n of Mets (median, IQR)	Mean diameter of LM, cm	Type of liver resection	Time to metastases detection or resection	Postop morbidity	Postop mortality	OS1 (median, months)	5-yr survival
Dünschede et al[23], 2010	4	42 (41–81)	1.75 (1–2)	2.2 (1–3)	NAR (3), Seg (1), HH (6)	92	0	0	31	0%
Hackert et al[31], 2017	23	60.4 (mean, for SM and MM)			NAR (14), Seg (3), HH (6)	18.43	34%	4.30%	14.8	-
Schwarz et al[26], 2020	25	63.8	1 (1,2)	-	NAR (8), Seg (15), HH (2)	17.83	32% CD1; 12% CD3	0%	36.8	0%
Zanini et al[30], 2015	4	48 (40.5-55.25)	1 (1-1)	2.2 (2-2.5)	NAR (3), HH (1)	8.02	25% CD3+; 75% overall	0%	11.4	0%

¹All median overall survival values are from liver metastases resection except Dünschede et al[23]. Which is reported from time of diagnosis.

²Time from primary resection to detection of LM.

³time from primary resection to resection of LM.

Seg: Segmentectomy; HH: Hemihepatectomy; NAR: Non-anatomical resection; CD: Clavien-Dindo; OS: Overall survival.