Resection of isolated liver oligometastatic disease in pancreatic ductal adenocarcinoma: Is there a survival benefit? A systematic review

Table 2 Synchronous isolated liver metastases resection outcomes

Ref.	n of patients	n of metastases (median, IQR)	Mean diameter of LM, cm	Type of liver resection	Primary resection R0 rate	Post op morbidity	Post op mortality	DFS (months)	OS (months)	5-yr survival
Dünschede et al[23], 2010	9	3 (1-5)	3.5 (1-9)	NAR (6), Seg (1), HH (2)	100%	33%	0%	-	8	0%
Hackert et al[31], 2017	62	-	-	NAR (59), Seg (2), HH (1)	-	47%	1.60%	-	10.6	-
Hamad et al[24], 2022	137	-	-	-	-	-	-	-	15.6	-
Klein et al[25], 2012	22	-	-	NAR (15), Seg (7)	32%	27%	0%	-	7.4	0%
Shi et al[32], 2016	30	-	-	-	-	-	-	-	15.7	3.3%
Tachezy et al[27], 2016	69	2 (1-2)	-	-	58%	68%	1%	-	14.5	5.8%
Takeda et al[28], 2023	5	2 (2-2)	-	-	-	23% CD3+	0%	20.9	33	-
Yang et al[29], 2020	48	-	-	NAR (43), Seg (4), HH (1)	100%	15%	4.1%	-	7.8	0%
Zanini et al[30], 2015	11	2 (1-2)	2.4 (1.75-2.5)	NAR (1), Seg (10)	-	27% CD3+; 54% overall	0%	5.2	9.1	0%

Seg: Segmentectomy; HH: Hemihepatectomy; NAR: Non-anatomical resection; CD: Clavien-Dindo; DFS: Disease free survival; OS: Overall survival.