Liver transplantation for combined hepatocellular carcinoma and cholangiocarcinoma: A multicenter study

Table 1 Baseline characteristics

	Before PSM			After PSM
	HCC (n = 141)	cHCC-CC (n = 111)	P value	HCC (n = 70)	cHCC-CC (n = 70)	P value
Donor
Sex (male)	89 (63.1)	69 (62.2)	0.896	47 (67.1)	45 (64.3)	0.859
Age (yr)	30 (16-68)	32 (11-60)	0.217	27 (16-63)	33 (11-58)	0.048
Body mass index (kg/m2)	23.1 (17.3-36.3)	23.0 (17.6-35.7)	0.679	23.3 (17.3-36.3)	23.5 (18.1-32.9)	0.839
Recipient
Sex (male)	127 (90.1)	95 (85.6)	0.329	65 (92.9)	60 (85.7)	0.274
Age (yr)	56 (37-70)	54 (31-66)	0.027	55 (37-60)	57 (31-66)	0.125
Body mass index (kg/m2)	24.3 (17.3-36.7)	24.0 (18.7-35.0)	0.35	23.9 (18.3-34.6)	24.1 (18.7-35.0)	0.94
Underlying liver disease			0.639			0.223
HBV	123 (87.2)	91 (82.0)		63 (90.0)	56 (80.0)
HCV	6 (4.3)	5 (4.5)		2 (2.9)	2 (2.9)
NBNC	6 (4.3)	8 (7.2)		1 (1.4)	6 (8.6)
Alcoholic	6 (4.3)	7 (6.3)		4 (5.7)	6 (8.6)
Diabetes	27 (19.1)	25 (22.5)	0.534	13 (18.6)	16 (22.9)	0.677
Hypertension	17 (12.1)	14 (12.6)	0.894	6 (8.6)	7 (10.0)	0.771
Child-Pugh class			0.613			0.914
A	66 (46.8)	46 (40.5)		30 (42.9)	30 (42.9)
B	44 (31.2)	43 (38.7)		24 (34.3)	25 (35.7)
C	31 (22.0)	23 (20.7)		16 (22.9)	15 (21.4)
MELD	10 (6-35)	11 (6-40)	0.455	11 (6-33)	11 (6-40)	0.82
WBC (/mL)	3300 (1050-16120)	3500 (1100-14300)	0.15	3325 (1050-16120)	3510 (1100-10700)	0.098
Hemoglobin (g/dL)	12.4 (6.0-16.7)	11.7 (5.9-16.4)	0.026	12.2 (7.3-15.5)	11.9 (7.0-15.9)	0.461
Platelets (1000/mL)	72000 (16000-233000)	43000 (26000-223000)	< 0.001	64500 (21000-233000)	42000 (26000-200000)	< 0.001
INR	1.20 (093-5.21)	1.25 (0.90-5.98)	0.183	1.21 (0.94-3.68)	1.23 (0.90-5.98)	0.91
Albumin (g/dL)	3.7 (2.4-4.8)	3.1 (1.8-4.7)	< 0.001	3.7 (2.4-4.8)	3.4 (1.8-4.7)	0.032
Total bilirubin (mg/dL)	1.2 (0.3-32.9)	1.5 (0.3-42.1)	0.078	1.3 (0.4-32.9)	1.4 (0.3-42.1)	0.778
AST (U/L)	37 (16-229)	42 (10-1387)	0.063	38 (16-192)	44 (10-1387)	0.137
ALT (U/L)	28 (7-205)	28 (6-1249)	0.437	26 (7-205)	29 (6-1249)	0.626
ALP (U/L)	90 (29-891)	102 (30-653)	0.013	100 (29-486)	98 (30-653)	0.423
Creatinine (mg/dL)	0.82 (0.44-1.75)	0.77 (0.20-4.58)	0.049	0.82 (0.57-1.38)	0.76 (0.20-4.58)	0.03

Data are presented as n (%) or median (range). HBV: Hepatitis B virus; HCV: Hepatitis C virus; NBNC: Non-B; non-C hepatitis; MELD: Model for end-stage liver disease; WBC: White blood cell; INR: International normalized ratio; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; PSM: Propensity score matching; HCC: Hepatocellular carcinoma; cHCC-CC: Combined hepatocellular carcinoma and cholangiocarcinoma.