Impact of interstitial cells of Cajal on slow wave and gallbladder contractility in a guinea pig model of acute cholecystitis

Figure 3 Effects of cholecystokinin octapeptide-induced contraction of gallbladder muscle strips. A: Destroying interstitial cells of Cajal can induce impairment of gallbladder muscle motility by loading methylene blue with light illumination [0.78 ± 0.08 vs 0.46 ± 0.04, ^aP < 0.01 vs normal control (NC) groups]; B: The cholecystokinin octapeptide-induced effect of the R value in the NC, AC12h, AC24h, and AC48h groups were 0.96 ± 0.21, 0.42 ± 0.09, 0.41 ± 0.03, and 0.20 ± 0.07, respectively (^bP < 0.05 vs NC groups, ^cP < 0.05 vs NC groups, ^dP < 0.01 vs NC groups). CCK-8: Cholecystokinin octapeptide; ICCs: Interstitial cells of Cajal; MB: Methylene blue; NC: Normal control; AC: Acute cholecystitis.