Impact of interstitial cells of Cajal on slow wave and gallbladder contractility in a guinea pig model of acute cholecystitis

Figure 2 Recording of the gallbladder slow wave by electromyogram. A and B: The mean slow wave (SW) frequency in the normal control (NC), methylene blue + light groups were 8.81 ± 0.25 vs 5.71 ± 0.43 (^dP < 0.001 vs NC groups); C and D: The mean SW frequency in the NC, acute cholecystitis 12 h (AC12h), AC24h, and AC48h groups were 10.66 ± 0.51, 7.13 ± 0.20, 6.46 ± 0.16, and 5.75 ± 0.44, respectively (^aP < 0.0001 vs NC groups, ^bP < 0.0001 vs NC groups, ^cP < 0.0001 vs NC groups); E: Illustration of a SW recording of the guinea pig gallbladder. SW: Slow wave; EMG: Electromyogram; NC: Normal control; AC: Acute cholecystitis; MB: Methylene blue.