Long-term outcomes and failure patterns after laparoscopic intersphincteric resection in ultralow rectal cancers

Table 4 Univariate and multivariate analyses through Cox regression for local recurrence-free survival

	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Age (> 60/ ≤ 60 yr)	1.318	0.442–3.931	0.620
Sex (female/male)	0.969	0.317–2.963	0.956
BMI (> 25/≤ 25 kg/m2)	1.263	0.413–3.860	0.683
CEA (> 5/≤ 5 ng/mL)	1.639	0.536–5.010	0.386
Tumor size (> 40/≤ 40 mm)	1.8332	0.615–5.451	0.277
Tumor height from anal verge (cm)	0.869	0.239–3.158	0.831
Lymphovascular invasion (yes/no)	2.897	0.889–9.436	0.077	1.056	0.287–3.884	0.935
Nerve invasion (yes/no)	2.812	0.771–10.258	0.117
(y)p T stage (3/1-2)	1.982	0.610–6.438	0.255
Lymph node metastasis (yes/no)	6.984	1.922–25.385	0.003	5.358	1.398–20.532	0.014
Differentiation (poor/well-moderate)	6.293	2.048–19.334	0.001	3.908	1.137–13.420	0.030
nCRT (yes/no)	2.731	0.750–9.940	0.127
Adjuvant therapy (yes/no)	2.357	0.726–7.653	0.154

BMI: Body mass index; CEA: Carcinoembryonic antigen; nCRT: Neoadjuvant chemoradiotherapy.