Acinous cell AR42J-derived exosome miR125b-5p promotes acute pancreatitis exacerbation by inhibiting M2 macrophage polarization via PI3K/AKT signaling pathway

Figure 2 Differentially expressed miRNAs in AR42J cell lines between non-activated and activated states were screened. A: RNA-seq was used to screen differentially expressed miRNAs. miRDB, miRWalk and Targetscan data were used to predict downstream binding target genes; B: The heat map and Volcano plot revealed that miR-125b-5p was up-regulated in activated state and down-regulated in non-activated state; C: The Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis was performed on target genes of differentially expressed miR-125b-5p, and KEGG top 40 signaling pathways were enriched. Among them, PI3K/AKT signaling pathway may be the signaling pathway of miR-125b-5p. AP: Acute pancreatitis.