Skeletal muscle mass and quality before preoperative chemotherapy influence postoperative long-term outcomes in esophageal squamous cell carcinoma patients

Table 2 Univariate and multivariate analyses of factors associated with overall survival

		1-year survival	3-year survival	5-year survival	Univariate analysis	P	Multivariate analysis	P
					Log rank		HR, 95%CI
Age, yr	≥ 60	88.0	58.0	51.1	5.604	0.018	2.031	0.054
	< 60	91.9	75.7	75.7			0.986-4.183
BMI	< 22	92.0	64.0	59.8	0.108	0.743
	≥ 22	87.3	62.6	57.4
PS	0	89.8	65.7	59.6	1.640	0.200
	1	81.8	45.5	45.5
ASA	2	87.2	60.4	55.7	1.812	0.178
	3	100.0	78.9	73.3
Stage	II	86.4	65.2	59.0	0.051	0.821
	III	91.9	61.0	57.6
PNI	≥ 50	87.5	58.9	58.9	0.006	0.937
	< 50	90.3	66.5	57.9
NLR	≥ 2.5	93.5	54.2	54.2	0.600	0.439
	< 2.5	87.7	66.0	59.8
mGPS	0	88.4	64.9	59.9	0.493	0.483
	1-2	92.0	56.0	52.0
GNRI	≥ 98	87.8	62.1	56.8	0.498	0.480
	< 98	93.3	66.7	63.3
Operative time (min)	≥ 450	89.1	63.2	55.4	0.039	0.843
	< 450	89.1	63.1	60.3
Blood loss (mL)	≥ 730	93.7	64.8	61.4	0.570	0.450
	< 730	84.6	61.5	55.4
Postoperative complication	Present	88.1	63.7	57.5	0.026	0.873
	Absent	89.7	62.8	58.9
pT	0-2	90.9	80.0	69.1	5.350	0.021	1.966	0.025
	3-	87.7	50.3	50.3			1.089-3.550
pN	0	93.5	82.6	73.7	7.465	0.006	2.154	0.022
	1-	86.7	52.1	49.6			1.118-4.148
IMAC	< -0.40	89.4	65.5	61.9	5.093	0.024	2.089	0.022
	≥ -0.40	87.4	44.8	29.9			1.036-4.214
PMI	≥ 4.0	93.6	70.1	64.5	7.096	0.008	2.266	0.005
	< 4.0	76.7	44.2	41.3			1.282-4.006

BMI: Body mass index; PMI: Psoas muscle mass index; IMAC: Intramuscular adipose tissue content.