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World J Gastrointest Surg. Apr 27, 2023; 15(4): 566-577
Published online Apr 27, 2023. doi: 10.4240/wjgs.v15.i4.566
Table 1 World Health Organization classification 2019 and grading criteria for neuroendocrine neoplasms of the gastrointestinal tract
Terminology
Differentiation
Grade
Ki-67 proliferative index (%)
Mitotic index (per 10 high-power fields)
NET, G1Well-differentiatedLow< 3< 2
NET, G2Well-differentiatedIntermediate3-202-20
NET, G3Well-differentiatedHigh> 20> 20
NEC, SCNECPoorly differentiatedHigh> 20> 20
NEC, LCNECPoorly differentiatedHigh> 20> 20
Mixed neuroendocrine-non-neuroendocrine neoplasmWell or poorly differentiatedVariableVariableVariable