Differential expression and significance of 5-hydroxymethylcytosine modification in hepatitis B virus carriers and patients with liver cirrhosis and liver cancer

Figure 2 Analysis of 5-hydroxymethylcytosine differences after sequencing. A, B: The gene volcano maps of hepatitis B surface antigen (HBsAg)-positive carriers and patients with liver cancer (A) and of patients with liver cirrhosis and those with liver cancer (B). The blue point indicates that the change of gene hydroxymethylation log2 fold is less than -0.26, and the red point indicates that the change of gene hydroxymethylation log2 fold is more than 0.26; C, D: Gene hot maps for HBsAg-positive carriers and patients with liver cancer (C) and for patients with liver cirrhosis and those with liver cancer (D). The blue block colors indicate a lower level of gene hydroxymethylation, and the red block colors indicate a higher level of gene hydroxymethylation. HBV: Hepatitis B virus.