Efficacy and safety of preoperative immunotherapy in patients with mismatch repair-deficient or microsatellite instability-high gastrointestinal malignancies

Table 3 Adverse events

Adverse events	No. of patients (%)	No. of patients (%)	No. of patients (%)
Immuno-related	Grade 1	Grade 2	Grade 3
Any	4 (11.1)	4 (11.1)	2 (5.6)
Dermatologic
Rash	2 (5.6)	0 (0)	0 (0)
RCCEP	1 (2.80)	0 (0)	0 (0)
Endocrine
Hypothyroidism	2 (5.6)	2 (5.6)	1 (2.80)
Hyperglycemia	0 (0)	0 (0)	0 (0)
Fatigue	3 (8.3)	4(11.1)	0 (0)
Surgery-related
Any	1 (2.80)	4(11.1)	1 (2.80)
Chylous fistula	0 (0)	2 (5.6)	0 (0)
Anastomosis leakage	0 (0)	2 (5.6)	0 (0)
Fever	1 (2.80)	0 (0)	0 (0)
Intra-abdominal hemorrhage	0 (0)	0 (0)	1 (2.80)

RCCEP: Reactive cutaneous capillary endothelial proliferation.