Hepatic vagotomy blunts liver regeneration after hepatectomy by downregulating the expression of interleukin-22

Figure 5 Treatment with interleukin-22BP can reduce the concentration of interleukin-22 and inhibit liver regeneration. A and B: The concentration of interleukin (IL)-22 in serum and liver tissue homogenate at each time point after partial hepatectomy (PHx) in the PHx-sham group and the PHx–IL-22BP group was counted; C: Representative BrdU staining pictures of liver tissue at different time points after PHx (200 ×); D: The percentage of BrdU⁺ hepatocytes (48 h) in the PHx-sham group and the PHx-IL-22BP group was calculated; E and F: We used an automatic chemical analyzer to detect the activities of serum alanine aminotransferase and aspartate aminotransferase in the PHx-sham group and the PHx–IL-22BP group (n = 4-8). ^aP < 0.05). PHx: Partial hepatectomy; Hv: Hepatic vagotomy; IL: Interleukin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.