Hepatic vagotomy blunts liver regeneration after hepatectomy by downregulating the expression of interleukin-22

Figure 1 Hepatic vagotomy inhibits liver regeneration and aggravates liver injury after partial hepatectomy. A: Representative BrdU staining pictures of liver tissue at different observation time points after partial hepatectomy (200 ×); B and C: The proportion of BrdU⁺ hepatocytes (48 h) and the liver weight/body weight ratio in each group were calculated to visually display the level of liver regeneration; D: Representative hematoxylin and eosin staining shows the area of liver injury after surgery (50 ×); E and F: Serum alanine aminotransferase and aspartate aminotransferase activities of mice in different groups were detected to determine the severity of liver injury (n = 6-10). ^aP < 0.05. PHx: Partial hepatectomy; Hv: Hepatic vagotomy; SP: Sham operation.