Association between the early high level of serum tacrolimus and recurrence of hepatocellular carcinoma in ABO-incompatible liver transplantation

Table 3 Cox-regression analyses for factors associated with HCC recurrence in recipients with hepatocellular carcinoma

	Univariate		Multivariate
	HR (95%CI)	P value	HR (95%CI)	P value
AFP > 200	4.07 (1.32-12.53)	0.014		NS
B-cell crossmatching, positive	0.29 (0.08-1.08)	0.065		NS
HLA-C mismatching	0.36 (0.12-1.11)	0.066		NS
Tacrolimus level, post-LT 4 wk	1.28 (1.00-1.65)	0.046	1.37 (1.04-1.80)	0.024
Over Milan – preoperative radiologic	13.11 (3.54-48.55)	< 0.001	8.61 (1.97-37.70)	0.004
Over Milan – pathologic	6.69 (2.05-21.83)	0.002		NS

HR: Hazard ratio; 95%CI: 95% confidence interval; AFP: Alpha-fetoprotein; HLA: Human leukocyte antigen; LT: Liver transplantation; NS: Not significant.