Association between the early high level of serum tacrolimus and recurrence of hepatocellular carcinoma in ABO-incompatible liver transplantation

Table 2 Cox-regression analyses for factors associated with graft survival in recipients without and with hepatocellular carcinoma

	Non-HCC				HCC
	Univariate		Multivariate		Univariate		Multivariate
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
B cell crossmatching, positive					0.19 (0.05-0.73)	0.016		NS
Tacrolimus level, post-LT 24 week	0.42 (0.23-0.88)	0.019	0.46 (0.23-0.91)	0.026
AMR	3.39 (0.70-16.36)	0.099		NS	11.33 (2.88-44.57)	0.001	63.20 (6.49-614.78)	< 0.001
HCC recurrence					5.31 (1.48-19.02)	0.010	20.72 (2.48-173.32)	0.005

HR: Hazard ratio; 95%CI: 95% confidence interval; HCC: Hepatocellular carcinoma; LT: Liver transplantation; AMR: Antibody mediated rejection; NS: Not significant.