Case Report
Copyright ©The Author(s) 2023.
World J Gastrointest Surg. Nov 27, 2023; 15(11): 2646-2656
Published online Nov 27, 2023. doi: 10.4240/wjgs.v15.i11.2646
Table 2 Description of patients with Cronkhite–Canada syndrome combined with hypothyroidism
Ref.
Age/sex
Country
Thyroid function
Ectodermal changes
Gastrointestinal symptoms
Treatment
Outcome
Størset et al[29], 197966/FSwedenT4 36 nmol/L, TSH 45.0 μU/mL, no thyroid antibodies detectedAlopecia, onychodystrophyDiarrhea, gastrointestinal polyposisThyroxine-sodiumImproved symptoms, but no changes in neurological and electromyographic findings
Jones et al[30], 198482/FUnited StatesTT4 1.0 µg/dL, TSH 31.5 mIU/mlAlopecia, onychodystrophy, hyperpigmentationDiarrhea, gastrointestinal polyposisPrednisone therapy was initiated at 20 mg/d orally, tapered to 10 mg/d within 2 wk, accompanied by nutritional supportImproved
Qiao et al[9], 200560/FChinaT3, TSH ↑, FT4 ↓Alopecia, nail dystrophy, hyperpigmentationDiarrhea, intermittent abdominal pain, generalized gastrointestinal polyposisSymptomatic treatmentsImproved
Berzin et al[8], 201272/MUnited StatesTSH 1.72 mIU/L (after supplementing with levothyroxine)Alopecia, onycholysis, and yellow nail discolorationDiarrhea, hypogeusia, early satiety, generalized gastrointestinal polyposisPrednisone 30 mg/d, symptomatic treatmentsDied
No author[31], 201655/FKoreaNDAlopecia, onychodystrophyDiarrhea with intermittent blood, nausea, abdominal pain, generalized gastrointestinal polyposisSteroids and nutritional supportImproved
No author[32], 201856/MUnited KingdomTSH 160 mIU/L, FT4 < 5 pmol/LAlopecia, onychodystrophy, hyperpigmentationDiarrhea, generalized gastrointestinal polyposisPrednisoloneImproved
Dawra et al[33], 201860/MIndiaTSH 94.65 µg/dLAlopecia, onychodystrophy, hyperpigmentationDiarrhea, anorexia, dysgeusia, multiple polypsCefixime, rifaximin, mesalamine, thyroid replacement, zinc supplementation (100 mg/d), along with micronutrient supplementationImproved