Case Report
Copyright ©The Author(s) 2023.
World J Gastrointest Surg. Nov 27, 2023; 15(11): 2627-2638
Published online Nov 27, 2023. doi: 10.4240/wjgs.v15.i11.2627
Table 1 Genetic testing and immunohistochemical data
Gene
Mutant/variation
Plasma
Esophagus
Duodenum
Liver
CDKN2Ac.322G>T (p.D108Y)-22.0%--
NF1c.6173 7127-1115del9.1%-3.2%0.9%
TP53c.560-2A>T0.1%15.4%--
TP53c.557 558delinsG-13.1%--
APCDeletion mutation7.8%-8.2%1.5%
CCND1Amplification-CN:5.1--
FGF19Amplification-CN:4.4--
MDM2Amplification--CN:4.4-
SMAD4c.456 478dup23.4%-17.1%5.9%
SMARCA4c.2506G>T (p.G836*)--6.9%-
CREBBPc.6666 6677del0.1%--3.4%
EP300c.4751 4752delinsAT-12.2%--
GATA3c.527 528delinsAG--2.1%-
RPTORc.2000T>C (p.L667P)-2.3%--
TMBs5.1/Mb (50.4%)8.2/Mb (29%)4.1/Mb (59.3%)3.1/Mb (68.9%)
Microsatellite analysisMSS/MSI-LMSS/MSI-LMSS/MSI-LMSS/MSI-L
MMR-related mutationsNoneNoneNoneNone
Immunohistochemistry
CR-
D2-40-
Ki67About 67%+About 70%+
P40+--
S-100+
SMA+
CAM5.2+
CD56-
CgA-
P63-
Syn-
CDH17-
CDX2Weak +
CK19+
CK20-
CK7+
SATB2-
TTF-
Villin+
Her2++
MLH1Complete expressionComplete expression
MSH2Complete expressionComplete expression
MSH6Complete expressionComplete expression
MSH6Complete expressionComplete expression
PD-L1< 1%+CPS < 1
EBER--
EGFR3+2+
VEGF--
CD15Part+-Part-
CD163+++
CD4About 5%+About 8%+About 10%+
CD68+++
CD8About 10%+About 5%+About 15%+