Effect of perioperative branched chain amino acids supplementation in liver cancer patients undergoing surgical intervention: A systematic review

Table 5 Intervention and control protocol for all included studies

Ref.	Intervention type	Intervention protocol1						Control protocol	Follow up period2
		Pre-operative regime	Total BCAA received (g)/d	Duration	Post-operative regime	Total BCAA received (g)/d	Duration		Intervention		Control
									Mean	Range	Mean	Range
Ardito et al[45], 2020	Preoperative, postoperative	BCAA 500 mg 2 tablets TDS with personalised diet (ERAS)	3	2/52	BCAA 500 mg 2 tablets TDS (ERAS)	3	1/12	Normal usual diet (ERAS)	NR	NR	NR	NR
Beppu et al[38], 2015	Preoperative, postoperative	Livact 4.15 g BD	8	6/12	NIL	NIL	NIL	Normal usual diet	NR	NR	NR	NR
Fan et al[43], 1994	Preoperative, postoperative	BCAA 1.5 g/kg	Weight dependent	1/52	BCAA 1.5 g/kg	Weight dependent	1/52	Normal usual diet	NR	NR	NR	NR
Hachiya et al[39], 2020	Postoperative	NIL	NIL	NIL	Livact 4 g TDS	12	4 yr	Normal usual diet	21.8	1.2-48	NR	NR
Ichikawa et al[40], 2013	Preoperative, postoperative	Livact 4.74 g TDS	12	2/52	Livact 4.74 g TDS	12	≥ 6/12	Normal usual diet	39.5 mo	7-48 mo	36.0 mo	6-50 mo
Ishikawa et al[30], 2010	Preoperative, postoperative	Aminoleban EN 50 g BD	11.123	2/52	Aminoleban EN 50 g BD	11.123	1/52	Normal usual diet	NR	NR	NR	NR
Kikuchi et al[41], 2016	Preoperative, postoperative	Livact 4.74 g TDS	12	1/12	Livact 4.74 g TDS	12	1 yr	Normal usual diet (35-40 kcal/kg/d) + 4.74 g Livact TDS × 1 yr post-operatively	NR	NR	NR	NR
Kobayashi et al[36], 2019	Preoperative, postoperative	Aminoleban EN 50 g ON	5.5615	2/52	Aminoleban EN ON	5.5615	12/52	Normal usual diet	NR	NR	NR	NR
Krapf et al[44], 2021	Postoperative	NIL	NIL	NIL	High BCAA diet	NA	2/52	Normal usual diet (standard isocaloric meal plan)	NR	NR	NR	NR
Meng et al[31], 1999	Postoperative	NIL	NIL	NIL	Aminoleban EN TDS with 40 g protein/d + 6300 kJ/d	NA	12/52	Normal usual diet (80 g protein/d + 6300 kJ/d)	511.6d	6-982 d	512.7d	48-983 d
Nagasue et al[32], 1997	Postoperative	NIL	NIL	2/52	Aminoleban EN 50 g BD	11.123	≥ 1 yr	Normal usual diet	35.8 mo (17.9)	NR	36.0 mo (17.7)	NR
Okabayashi et al[35], 2008	Preoperative	Aminoleban EN 50 g BD	11.123	2/52	NIL	NIL	NIL	Normal usual diet	16.3 mo	2-47 mo	23.3 mo	2-84 mo
Okabayashi et al[33], 2010	Preoperative	Aminoleban EN 50 g BD	11.123	2/52	NIL	NIL	NIL	Normal usual diet	NR	NR	NR	NR
Okabayashi et al[34], 2011	Preoperative, postoperative	Aminoleban EN 50 g BD	11.123	2/52	Aminoleban EN 50 g BD	11.123	≥ 6/12	Normal usual diet	NR	NR	NR	NR
Shirabe et al[37], 2011	Preoperative	Regime 1: Livact 3 packets OD Regime 2: Aminoleban EN 50 g 1 to 3 packets	Regime 1: 12Regime 2: 5.5615-16.6845	> 1/12	NIL	NIL	NIL	Normal usual diet	NR	NR	NR	NR
Togo et al[42], 2005	Post-operative	NIL	NIL	NIL	Livact 4.74 g TDS	12	1 yr	Normal usual diet	NR	NR	NR	NR

¹Composition of livact and Aminoleban described in supplementary table 4.

²Data is expressed as n or mean +/- SD (median, range).

Participants on branched chain amino acid supplementation were also taking normal usual diet. BCAA: Branched chain amino acid; ERAS: Enhanced recovery after surgery; TDS: Ter die sumendum ; NR: Not reported; NIL: Nothing.