Effect of perioperative branched chain amino acids supplementation in liver cancer patients undergoing surgical intervention: A systematic review

Table 3 Relevant surgical details of included studies

Ref.	Surgical method		Intervention	Control	Blood loss/mL1
					Intervention	Control
Ardito et al[45], 2020	Hepatectomy	Minimally invasive liver surgery	33	74	NR	NR
		Major hepatic resection	16	62
		Multiple resections	43	44
		Total	92	180
Beppu et al[38], 2015	Hepatectomy	Right hemihepatectomy	8	7	NR	NR
		Left hemihepatectomy	0	1
		Sectionectomy	1	3
		Left hemihepatectomy + sectionectomy	0	1
		Total	9	12
Fan et al[43], 1994	Hepatectomy	Major hepatic resection	47	42	2600 (300-20000)	1900 (400-10500)
		Minor hepatic resection	17	18
		Total	64	60
Hachiya et al[39], 2020	Hepatectomy	Non-anatomical resections	19	25	348 (5-3400)	359 (5-3741)
		Anatomical resections	55	55
		Total	74	80
Ichikawa et al[40], 2013	Hepatectomy	Major hepatic resection	10	14	716 +/- 704	492 +/- 329
		Limited resection of the liver	16	16
		Total	26	30
Ishikawa et al[30], 2010	Hepatectomy	Major hepatic resection	7	5	802.7 +/- 350.6	838.8 +/- 597.6
		Minor hepatic resection	6	8
		Total	13	13
Kikuchi et al[41], 2016	Hepatectomy	Partial hepatectomy	13	12	665.7 +/- 528.9	578.5 +/- 492.1
		Segmentectomy	0	6
		Bisgmentectomy/sectionectomy	13	10
		Bisectionectomy or more	13	10
		Total	39	38
Kobayashi et al[36], 2019	Hepatectomy	Major hepatic resection	4	0	454 (140-5103)	365 (35-3650)
		Minor hepatic resection	22	10
		Total	26	10
Krapf et al[44], 2021	Liver transplant- Hepatectomy	Major hepatic resection	24	12	NR	NR
		Hepatic resection	9	12
		Total	33	24
Meng et al[31], 1999	Hepatectomy	Major hepatic resection	13	18	NR	NR
		Minor hepatic resection	8	5
		Total	21	23
Nagasue et al[32], 1997	Hepatectomy	Major hepatic resection	19	26	NR	NR
		Minor hepatic resection	48	39
		Total	67	65
Okabayashi et al[35], 2008	Hepatectomy	Major hepatic resection	10	19	516 +/- 354	821 +/- 552
		Minor hepatic resection	30	53
		Total	40	72
Okabayashi et al[33], 2010	Hepatectomy	Major hepatic resection	5	7	1252 +/- 1205	669 +/- 575
		Minor hepatic resection	8	6
		Total	13	13
Okabayashi et al[34], 2011	Hepatectomy	Hemihepatectomy	4	4	945 +/- 827	676 +/- 695
		Segmentectomy	12	10
		Limited hepatic resection	24	22
		Total	40	36
Shirabe et al[37], 2011	Liver transplant	Total	129	107	7388 +/- 9031	6448 +/- 6547
Togo et al[42], 2005	Hepatectomy	Partial hepatectomy	8	8	1163 +/- 853	1209 +/- 872
		Segmentectomy	7	8
		Sectionectomy	4	3
		Hemihepatectomy	2	3
		Total	21	22

¹Data is expressed as n or mean +/- SD (median, range).

NR: Not reported.