Risk and management of post-operative infectious complications in inflammatory bowel disease: A systematic review

Table 9 Anti-tumor necrosis factor therapy

Ref.	Year	Cohort	Studies	Results
Billioud et al[30]	2013	UC an-d CD	Meta-analysis	Slight increase in overall post-operative complications, infectious complications in CD patients in particular
Ahmed Ali et al[31]	2014	CD	Meta-analysis	Increased wound infection and sepsis
Yang et al[33]	2014	CD	Meta-analysis; 10 studies	Modest increase in post-operative infectious complications
Narula et al[32]	2013	UC and CD	Meta-analysis; 15 studies	Modest increase in post-operative infectious complications
Law et al[14]	2020	UC and CD	Systematic review; Cochrane	Increased infectious complications in CD patients when treatment started within 8 wk of surgery
Yang et al[35]	2012	UC	Meta-analysis; 13 studies	No increase in post-operative early complications
Rosenfeld et al[36]	2013	CD	Systematic review and meta-analysis: 6 studies; 1159 patients	No significant difference in major complications noted between infliximab and control groups
Xu et al[34]	2019	CD	Meta-analysis: 14 studies for infectious complications	No increased risk of post-operative infection with preoperative infliximab
Cohen et al[15]	2019	UC and CD	Prospective	No increase in infection or SSI

CD: Crohn’s disease; UC: Ulcerative colitis; SSI: Surgical site infection.