Risk and management of post-operative infectious complications in inflammatory bowel disease: A systematic review

Table 1 Hypoalbuminemia

Ref.	Year	Studies	Cohort	Results
Nguyen et al[8]	2019	Retrospective (2005-2012)	CD and UC	Moderate to severe hypoalbuminemia is associated with increased post-operative infection: CD 20% vs 13%, P < 0.01; UC 28% vs 15%, P < 0.01. In the case of severe hypoalbuminemia, increased risk of intra-abdominal infection, sepsis, shock and pneumonia; additional risk for urinary tract infection in UC
Huang et al[5]	2015	Meta-analysis: 8 studies for hypoalbuminemia: Cohort; case control; case control; case control; case control; case control; cohort; case control	CD	Hypoalbuminemia is a risk factor for infectious complications
Liu et al[19]	2017	Retrospective 2014-2016	CD	Increased surgical site infection with hypoalbuminemia
Ghoneima et al[4]	2019	Retrospective 2012-2017	CD	Hypoalbuminemia is a predictive risk for septic complications especially if associated with anemia and high CRP
Yang et al[20]	2012	Retrospective 1991-2010	CD	Preoperative albumin < 30 g/L increased the risk of post-operative complication by 2.6 fold

CD: Crohn’s disease; UC: Ulcerative colitis; CRP: C-reactive protein.