Multi-national observational study to assess quality of life and treatment preferences in patients with Crohn’s perianal fistulas

doi:10.4240/wjgs.v15.i11.2537

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Nov 27, 2023 (publication date) through Jul 28, 2024

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

World J Gastrointest Surg. Nov 27, 2023; 15(11): 2537-2552
Published online Nov 27, 2023. doi: 10.4240/wjgs.v15.i11.2537

Table 4 Medication and surgical experience

	Cohort 1	Cohort 2	Cohort 3	Cohorts 2 + 3
	All non-PF CD (n = 620)	CPF no surgery (n = 174)	CPF with surgery (n = 135)	All CPF (n = 309)
CD-related medication experience, n (%)
Currently taking	429 (69)^a^,^b^,^c	147 (84)^d	108 (80)^d	255 (83)^d
Previously taken	155 (25)^a^,^b^,^c	27 (16)^d	22 (16)^d	49 (16)^d
Never taken	36 (6)^a^,^c	0^b^,^d	5 (4)^a	5 (2)^d
CD-related surgical experience
Frequency of surgical experience ever, n (%)	190 (31)^a^,^b^,^c	78 (45)^b^,^d	119 (88)^a^,^d	197 (64)^d
Number of surgeries in the past 12 mo (mean ± SD)	1.5 (0.9)^b^,^c	1.8 (1.1)^b	2.2 (1.3)^a^,^d	2.0 (1.3)^d
Number of surgeries in the past 12 mo (median)	1^e	1^e	2^e	2^e
Frequency of surgical failure ever, n (%)	52 (27)^b^,^c	22 (28)^b	55 (46)^a^,^d	77 (39)^d
Number of failed surgeries ever (mean ± SD)	1.7 (2.1)^e	2.2 (1.6)^e	1.9 (1.8)^e	2.0 (1.7)^e
Number of failed surgeries ever (median)	1^e	2^e	1^e	1^e
PF-related surgical care
PF-related procedure or surgery frequency (mean ± SD)	NA	NA	5.6 (3.5)^e	NA
One PF-related procedure or surgery	NA	NA	9 (7)^e	NA
Two PF-related procedures or surgeries	NA	NA	21 (16)^e	NA
Three or more PF-related procedures or surgeries	NA	NA	105 (78)^e	NA
Failure of PF-related procedure or surgical care (at any time) ever, n (%)
One failed PF-related procedure or surgery	NA	NA	35 (26)^e	NA
Two or more failed PF-related procedure or surgery	NA	NA	19 (14)^e	NA

^aP < 0.05 vs cohort 2.

^bP < 0.05 vs cohort 3.

^cP < 0.05 vs cohort 2 + 3 combined.

^dP < 0.05 vs cohort 1.

^eNo statistically significant difference versus any other cohort.

P values are shown where there is a statistically significant difference between specified cohorts. Bonferroni adjustment was applied when comparing more than 2 groups at P < 0.05. CD: Crohn’s disease; CPF: Crohn’s perianal fistulas; NA: Not applicable; PF: Perianal fistulas.

Citation: Karki C, Athavale A, Abilash V, Hantsbarger G, Geransar P, Lee K, Milicevic S, Perovic M, Raven L, Sajak-Szczerba M, Silber A, Yoon A, Tozer P. Multi-national observational study to assess quality of life and treatment preferences in patients with Crohn’s perianal fistulas. World J Gastrointest Surg 2023; 15(11): 2537-2552
URL: https://www.wjgnet.com/1948-9366/full/v15/i11/2537.htm
DOI: https://dx.doi.org/10.4240/wjgs.v15.i11.2537