Multi-national observational study to assess quality of life and treatment preferences in patients with Crohn’s perianal fistulas

doi:10.4240/wjgs.v15.i11.2537

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Nov 27, 2023 (publication date) through Jul 28, 2024

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

World J Gastrointest Surg. Nov 27, 2023; 15(11): 2537-2552
Published online Nov 27, 2023. doi: 10.4240/wjgs.v15.i11.2537

Table 3 Disease presentation and symptom severity

	Cohort 1	Cohort 2	Cohort 3	Cohorts 2 + 3
	All non-PF CD (n = 620)	CPF no surgery (n = 174)	CPF with surgery (n = 135)	All CPF (n = 309)
Ever experienced fecal incontinence, n (%)	251 (40)^a^,^b^,^c	103 (59)^d	80 (59)^d	183 (59)^d
More than 5 CD complications, n (%)	266 (43)^a^,^b^,^c	135 (78)^d	111 (82)^d	246 (80)^d
PF experience
Number of unique PFs (mean ± SD)	NA	2.3 (1.4)^b	3.0 (3.0)^a	NA
Experience with PF recurrence/persistence, n (%)	NA	84 (48)^e	80 (59)^e	NA
CD severity (physician classified) at diagnosis, n (%)
Mild	187 (30)^a^,^b^,^c	24 (14)^d	23 (17)^d	47 (15)^d
Moderate	298 (48)^a^,^b^,^c	123 (71)^b^,^d	78 (58)^a^,^d	201 (65)^d
Severe	86 (14)^b	22 (13)^b	31 (23)^a^,^d	53 (17)^e
Not sure	49 (8)^a^,^b^,^c	5 (3)^d	3 (2)^d	8 (3)^d

^aP < 0.05 vs cohort 2.

^bP < 0.05 vs cohort 3.

^cP < 0.05 vs cohort 2 and 3 combined.

^dP < 0.05 vs cohort 1.

^eNo statistically significant difference versus any other cohort.

P values are shown where there is a statistically significant difference between specified cohorts. Bonferroni adjustment was applied when comparing more than 2 groups at P < 0.05. CD complications include reported frequency of intestinal obstructions, perianal abscesses, fissures, malabsorption and malnutrition, diarrhea, small intestinal bacterial overgrowth, megacolon, perforation of the intestine, colovesical fistulas, coloenteric fistulas, rectovaginal fistulas, multiple fistulas, anorectal strictures, fistulas in the upper part of the sphincter complex, enterocutaneous fistulas, ulcer, severe bleeding, intestinal strictures neoplasm, and “other”. CD: Crohn’s disease; CPF: Crohn’s perianal fistulas; NA: Not applicable; PF: Perianal fistulas.

Citation: Karki C, Athavale A, Abilash V, Hantsbarger G, Geransar P, Lee K, Milicevic S, Perovic M, Raven L, Sajak-Szczerba M, Silber A, Yoon A, Tozer P. Multi-national observational study to assess quality of life and treatment preferences in patients with Crohn’s perianal fistulas. World J Gastrointest Surg 2023; 15(11): 2537-2552
URL: https://www.wjgnet.com/1948-9366/full/v15/i11/2537.htm
DOI: https://dx.doi.org/10.4240/wjgs.v15.i11.2537