Multi-national observational study to assess quality of life and treatment preferences in patients with Crohn’s perianal fistulas

doi:10.4240/wjgs.v15.i11.2537

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Nov 27, 2023 (publication date) through Jan 6, 2025

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

World J Gastrointest Surg. Nov 27, 2023; 15(11): 2537-2552
Published online Nov 27, 2023. doi: 10.4240/wjgs.v15.i11.2537

Table 2 Baseline demographics and patient characteristics

	Cohort 1	Cohort 2	Cohort 3	Cohorts 2 + 3
	All non-PF CD (n = 620)	CPF no surgery (n = 174)	CPF with surgery (n = 135)	All CPF (n = 309)
Sex, n (%)
Male	360 (58)^a	116 (67)^b	93 (69)^b	209 (68)^c
Age, yr, n (%)¹
21-40	340 (55)^a^,^d^,^e	112 (64)^c	90 (67)^c	202 (65)^c
41-60	208 (34)^b	59 (34)^b	44 (33)^b	103 (33)^b
61-80	72 (12)^a^,^d^,^e	3 (2)^c	1 (1)^c	4 (1)^c
CD flare-up status, n (%)
Recent flare-up	270 (44)^a^,^e	85 (49)^e	87 (64)^c^,^d	172 (56)^c
Comorbidities, n (%)
Asthma	88 (14)^b	27 (16)^b	30 (22)^b	57 (18)^b
Obesity	87 (14)^b	31 (18)^b	22 (16)^b	53 (17)^b
Cardiovascular disease	33 (5)^a^,^e	13 (7)^b	17 (13)^c	30 (10)^c
COPD	17 (3)^e	4 (2)^d	11 (8)^c^,^d	15 (5)^b
Cancer	22 (4)^b	7 (4)^b	7 (5)^b	14 (5)^b
Renal disease	14 (2)^b	6 (3)^b	6 (4)^b	12 (4)^b

^aP < 0.05 vs cohort 2 and 3 combined.

^bNo statistically significant difference versus any other cohort.

^cP < 0.05 vs cohort 1.

^dP < 0.05 vs cohort 2.

^eP < 0.05 vs cohort 3.

¹None of the patients were aged < 21 or > 80 yr.

P values are shown where there is a statistically significant difference between specified cohorts. Bonferroni adjustment was applied when comparing more than 2 groups at P < 0.05. CD: Crohn’s disease; COPD: Chronic obstructive pulmonary disease; CPF: Crohn’s perianal fistulas; PF: Perianal fistulas.

Citation: Karki C, Athavale A, Abilash V, Hantsbarger G, Geransar P, Lee K, Milicevic S, Perovic M, Raven L, Sajak-Szczerba M, Silber A, Yoon A, Tozer P. Multi-national observational study to assess quality of life and treatment preferences in patients with Crohn’s perianal fistulas. World J Gastrointest Surg 2023; 15(11): 2537-2552
URL: https://www.wjgnet.com/1948-9366/full/v15/i11/2537.htm
DOI: https://dx.doi.org/10.4240/wjgs.v15.i11.2537