Correlation between pre-treatment serum total blood bilirubin and unconjugated bilirubin and prognosis in patients with colorectal cancer

Table 3 Cox regression analysis affecting the prognosis of colorectal cancer patients

Variable		Univariate analysis			Multivariate analysis
		HR	95%CI	P value	HR	95%CI	P value
Age (yr)		1.017	0.989-1.046	0.234	-
Sex	Male
	Female	0.805	0.468-1.384	0.433	-
Grade	High	1			1
	Middle	4.664	1.888-11.521	0.001	2.619	0.939-7.303	0.066
	Low	39.435	16.469-94.427	< 0.001	22.873	7.092-73.769	< 0.001
Diameter	< 5 cm
	≥ 5 cm	2.287	1.315-3.980	0.003	0.927	0.494-1.741	0.814
Lymph node metastasis	No
	Yes	17.672	7.815-39.963	< 0.001	9.129	1.157-73.485	0.036
TNM	Ⅰ	1			1
	Ⅱ	7.235	3.023-17.315	< 0.001	0.998	0.121-8.218	0.999
	Ⅲ	19.778	8.461-46.235	< 0.001	1.124	0.125-10.088	0.917
Smoking	No
	Yes	2.357	1.424-3.093	0.001	0.800	0.444-1.442	0.458
TBIL (μmol/L)	≤ 13.45
	> 13.45	0.282	0.160-0.495	< 0.001	0.360	0.159-0.812	0.014
UCB (μmol/L)	≤ 10.75
	> 10.75	0.178	0.093-0.344	< 0.001	0.986	0.385-2.526	0.977

TBIL: Total bilirubin; UCB: Unconjugated bilirubin; TNM: Tumour, node, and metastasis; CI: Confidence interval; HR: Hazard Ratio.