Predicting lymph node metastasis in colorectal cancer: An analysis of influencing factors to develop a risk model

Table 2 Representative patches of tumor tissue for each of the top 10 clusters

Cluster	Description
1	Poorly differentiated tumor cells with a high nuclear-cytoplasmic ratio, irregular glandular formation, and sparse stroma
2	Well-differentiated tumor cells with low nuclear-cytoplasmic ratio, regular glandular formation, and abundant stroma
3	Tumor cells with moderate differentiation, moderate nuclear-cytoplasmic ratio, and moderate stroma
4	Tumor cells with signet-ring cell differentiation, high nuclear-cytoplasmic ratio, and mucin production
5	Tumor cells with neuroendocrine differentiation, high nuclear-cytoplasmic ratio, and rosette-like structures
6	Tumor cells with serrated adenocarcinoma differentiation, low nuclear-cytoplasmic ratio, and serrated glandular formation
7	Tumor cells with mucinous differentiation, low nuclear-cytoplasmic ratio, and abundant extracellular mucin
8	Tumor cells with medullary carcinoma differentiation, high nuclear-cytoplasmic ratio, and solid growth pattern
9	Tumor cells with micropapillary carcinoma differentiation, high nuclear-cytoplasmic ratio, and papillary projections
10	Tumor cells with mixed adenoneuroendocrine carcinoma differentiation, high nuclear-cytoplasmic ratio, and dual expression of neuroendocrine and epithelial markers