Identification of multiple risk factors for colorectal cancer relapse after laparoscopic radical resection

Table 1 Comparison of baseline data, n (%)

Criteria	Relapse group (n = 30)	Non-relapse group (n = 110)	Statistical values (χ2/t)	P value
Gender
Male	20 (66.67)	60 (54.55)	0.414	0.234
Female	10 (33.33)	50 (45.45)
Age (year)
≥ 60	18 (60.00)	70 (63.64)	0.134	0.715
< 60	12 (40.00)	40 (36.36)
TNM stage
Ⅰ-Ⅱ	15 (50.00)	65 (59.09)	0.796	0.372
Ⅲ-Ⅳ	15 (50.00)	45 (40.91)
Differentiation
Low	25 (83.33)	23 (20.91)	40.768	< 0.001
Medium/high	5 (16.67)	87 (79.09)
Tumor maximum diameter (cm)
≥ 5	20 (66.67)	65 (59.09)	0.567	0.451
> 5	10 (33.33)	45 (40.91)
Lesion location
Rectum	24 (80.00)	25 (22.73)	33.986	< 0.001
left/right hemicolon	6 (20.00)	85 (77.27)
Lymphatic vascular invasion
Present	22 (73.33)	20 (18.18)	34.141	< 0.001
Absent	8 (26.67)	90 (81.82)
Postoperative adjuvant therapy
Not done or incomplete	15 (50.00)	60 (54.55)	χ2 = 0.196	0.658
Complete	15 (50.00)	50 (45.45)
Pathological type
Glandular cancer	10 (33.33)	30 (27.27)	0.951	0.622
Mucinous adenocarcinoma	8 (26.67)	25 (22.73)
Indian cell carcinoma	12 (40.00)	55 (50.00)
Infiltration depth
T1 + T2	18 (60.00)	70 (63.64)	0.134	0.715
T3 + T4	12 (40.00)	40 (36.36)
Immune indicators
CD4+/CD8+	1.02 ± 0.26	1.48 ± 0.38	6.236	< 0.001
IgG (g/L)	4.14 ± 0.60	5.72 ± 0.94	8.722	< 0.001
IgA (g/L)	0.50 ± 0.08	0.69 ± 0.14	7.111	< 0.001
IgM (g/L)	0.68 ± 0.22	0.95 ± 0.32	4.344	< 0.001
NLR	4.18 ± 0.95	3.42 ± 0.55	5.636	< 0.001
AGR	1.60 ± 0.40	1.98 ± 0.36	0.003	< 0.001
Tumor indicators
CYFRA21-1 (ng/mL)	4.78 ± 0.52	3.25 ± 0.35	13.369	< 0.001
VEGF (ng/L)	190.12 ± 50.25	140.12 ± 42.25	4.171	< 0.001
PNI	40.75 ± 2.02	43.21 ± 2.18	4.534	< 0.001
YKL-40 (ng/mL)	104.25 ± 20.52	78.95 ± 15.25	5.420	< 0.001

TNM: Tumor node metastasis; Ig: Immunoglobulins; NLR: Neutrophils to lymphocytes ratio; AGR: Albumin-globulin ratio; CYFRA21-1: Cytokeratin 19 fragment antigen 21-1; VEGF: Vascular endothelial growth factor; PNI: Prognostic nutritional index; YKL-40: Inflammatory biomarker Chitinase-3-like protein 1.