Gene polymorphisms associated with sudden decreases in heart rate during extensive peritoneal lavage with distilled water after gastrectomy

Table 9 Best single nucleotide polymorphism-single nucleotide polymorphism interaction models identified by generalized multifactor dimensionality reduction with covariable adjustment (heart rate variability cutoff value = 30%)

Best model	Training balanced accuracy	Testing balanced accuracy	Cross-validation consistency	P value
rs820196	0.6116	0.6127	10/10	0.032a
rs938886, rs820196	0.6495	0.5782	10/10	0.151
rs938886, rs820196, rs1713449	0.6495	0.5753	10/10	0.168

^aP < 0.05 means the one-locus model of RecQ like helicase 5 rs820196 is the best model for predicting heart rate variability risk.

Logistic regression analyses adjusting for age, gender, smoking, hypertension, and thyroid function.