Gene polymorphisms associated with sudden decreases in heart rate during extensive peritoneal lavage with distilled water after gastrectomy

Table 15 Single nucleotide polymorphism-smoking, single nucleotide polymorphism-hypertension and SNP-thyroid function interaction models in patients with heart rate variability ≥ 15% evaluated with the generalized multifactor dimensionality reduction approach

Best model	Training balanced accuracy	Testing balanced accuracy	CVC	P value
SNP-smoking interaction1
Smoking	0.5191	0.5171	10/10	0.349
rs820196-smoking	0.6148	0.5954	10/10	0.022a
rs820196-rs1713449-smoking	0.6510	0.5764	9/10	0.065
SNP-hypertension interaction2
Hypertension	0.5156	0.3564	10/10	0.995
rs820196-hypertension	0.5885	0.5920	10/10	0.043b
rs820196-rs1713449-hypertension	0.6434	0.5343	9/10	0.219
SNP-thyroid function interaction3
Thyroid function	0.5126	0.5113	10/10	0.381
rs820196-thyroid function	0.5888	0.5814	10/10	0.065
rs820196-rs1713449-thyroid function	0.6411	0.5706	9/10	0.075

^aP < 0.05 means rs820196-smoking two-factor model associated with Heart rate variability (HRV) ≥ 15%.

^bP < 0.05 means rs820196-hypertension two-factor model associated with HRV ≥ 15%.

¹Adjusted for age, gender, hypertension, and thyroid function.

²Adjusted for age, gender, smoking, and thyroid function.

³Adjusted for age, gender, smoking, and hypertension.

SNP: Single nucleotide polymorphism; CVC: Cross-validation consistency.