Gene polymorphisms associated with sudden decreases in heart rate during extensive peritoneal lavage with distilled water after gastrectomy

Table 13 Best single nucleotide polymorphism-single nucleotide polymorphism interaction models identified by generalized multifactor dimensionality reduction with covariable adjustment (heart rate variability cutoff value = 15%)

Best model	Training balanced accuracy	Testing balanced accuracy	CVC	P value
rs820196	0.5885	0.5920	10/10	0.039a
rs820196, rs1713449	0.6301	0.5798	9/10	0.052
rs938886, rs820196, rs1713449	0.6335	0.5885	10/10	0.066

^aP < 0.05 means the one-locus model of RecQ like helicase 5 rs820196 is the best model for predicting heart rate variability risk.

Adjusted for age, gender, hypertension, smoking, and thyroid function. CVC: Cross-validation consistency.