Gene polymorphisms associated with sudden decreases in heart rate during extensive peritoneal lavage with distilled water after gastrectomy

Table 11 Single nucleotide polymorphism-smoking, single nucleotide polymorphism -hypertension, and single nucleotide polymorphism-thyroid function interaction models in patients with heart rate variability ≥ 30% evaluated with the generalized multifactor dimensionality reduction approach

Best model	Training balanced accuracy	Testing balanced accuracy	CVC	P value
SNP-smoking interaction1
Smoking	0.5265	0.5135	10/10	0.263
rs820196-smoking	0.6281	0.6021	10/10	0.045a
rs938886-rs820196-smoking	0.6703	0.5947	8/10	0.099
SNP-hypertension interaction2
Hypertension	0.5292	0.3308	10/10	0.800
rs820196-hypertension	0.6117	0.5648	10/10	0.190
rs820196-rs1713449-hypertension	0.6996	0.5063	8/10	0.426
SNP-thyroid function interaction3
Thyroid function	0.5123	0.4980	10/10	0.194
rs820196-thyroid function	0.6263	0.5895	10/10	0.104
rs938886-rs820196-thyroid function	0.6665	0.5727	8/10	0.153

^aP < 0.05 means rs820196-smoking two-factor model associated with HRV ≥ 30%.

¹Adjusted for age, gender, hypertension, and thyroid function.

²Adjusted for age, gender, smoking, and thyroid function.

³Adjusted for age, gender, smoking, and hypertension.

SNP: Single nucleotide polymorphism; CVC: Cross-validation consistency.