Prognostic effect of excessive chemotherapy cycles for stage II and III gastric cancer patients after D2 + gastrectomy

Table 5 Subgroup analysis of overall survival by Cox regression analysis of stage III gastric cancer patients

Variables	Death	Total	HR	95%CI	P value	P for interaction
Sex						0.639
Male	198	360	1.258	0.951-1.664	0.108
Female	72	124	0.925	0.582-1.470	0.741
Depth of tumor invasion						0.127
T3	43	123	1.044	0.569-1.916	0.888
T4	227	361	1.207	0.929-1.567	0.158
Number of positive lymph nodes						0.007
≤ 6	91	197	1.312	0.867-1.988	0.199
≥ 7	179	287	1.115	0.832-1.496	0.466
Vascular invasion						0.099
Negative	58	119	1.365	0.818-2.277	0.233
Positive	211	365	1.138	0.868-1.492	0.350
Neural invasion						0.059
Negative	73	159	1.389	0.872-2.211	0.166
Positive	197	325	1.114	0.842-1.474	0.451
Lauren classification						0.002
Intestinal	39	88	1.196	0.873-1.640	0.264
Diffuse	168	254	1.184	0.872-1.606	0.280
Mixed	63	142	0.975	0.760-1.250	0.840
Maximum diameter of tumor in cm						< 0.001
< 6	108	230	1.071	0.734-1.563	0.722
≥ 6	162	254	1.240	0.909-1.692	0.174
Type of gastrectomy						0.004
Proximal	13	25	1.175	0.680-2.032	0.564
Distal	65	142	0.915	0.560-1.494	0.722
Total	192	317	1.125	0.976-1.297	0.105

CI: Confidence interval; HR: Hazard ratio.