Prognostic effect of excessive chemotherapy cycles for stage II and III gastric cancer patients after D2 + gastrectomy

Table 3 Subgroup analysis of progression-free survival by Cox regression analysis of chemotherapy cycles of stage II gastric cancer

Variables	Death or recurrence	Total	HR	95%CI	P value	P for interaction
Sex						0.385
Male	33	156	0.788	0.426-1.459	0.449
Female	22	38	0.495	0.149-1.646	0.252
Depth of tumor invasion						0.226
T1/T2	9	29	0.827	0.227-3.109	0.779
T3/T4	46	165	0.670	0.368-1.219	0.190
Number of positive lymph nodes						0.842
0	28	101	0.519	0.232-1.159	0.110
≥ 1	27	93	0.895	0.420-1.905	0.773
Vascular invasion						0.743
Negative	23	128	1.225	0.536-1.798	0.630
Positive	32	66	0.454	0.200-0.988	0.047
Neural invasion						0.732
Negative	35	163	0.649	0.328-1.286	0.216
Positive	20	93	0.878	0.348-2.212	0.782
Lauren classification						0.622
Intestinal	20	99	0.833	0.344-2.015	0.685
Diffuse	15	40	0.582	0.207-1.639	0.306
Mixed	20	55	0.839	0.323-2.177	0.718
Maximum diameter of tumor in (cm)						0.128
< 6	33	145	0.642	0.317-1.301	0.219
≥ 6	22	49	0.883	0.370-2.106	0.779
Type of gastrectomy						0.356
Proximal	5	18	0.716	0.115-4.443	0.720
Distal	17	58	0.521	0.181-1.501	0.227
Total	35	118	0.779	0.389-1.503	0.483
HER2						0.200
Negative	29	109	0.851	0.408-1.772	0.665
Positive	26	85	0.549	0.242-1.245	0.151

CI: Confidence interval; HR: Hazard ratio.