Postoperative adjuvant therapy for hepatocellular carcinoma with microvascular invasion

Table 4 Adjuvant therapy after liver transplantation

Ref.	Interventions	Characteristics	n	Result	PMID
Rodríguez-Perálvarez et al[53]	Drug: mTOR inhibitors	Multicenter retrospective study	219	Effective	23867318
Vivarelli et al[54]	Drug: Cyclosporine	Retrospective study	70	Effective	15838913
Vivarelli et al[55]	Drug: Tacrolimus	Retrospective study	139	Ineffective	18948815
Geissler et al[56]	Drug: Sirolimus	Phase: 3. Allocation: Randomized. Intervention model: Parallel	525	Ineffective	26555945
Friend et al[78]	Drug: Nivolumab	Retrospective study	2	Ineffective	28643391
Biondani et al[60]	Drug: Nivolumab	Case report	1	Ineffective	29293878
DeLeon et al[61]	Drug: PD-1/PD-L1 inhibitors	Retrospective study	7	Partly effective	30603124
Gassmann et al[63]	Drug: Nivolumab	Case report	1	Ineffective	30255136
Varkaris et al[65]	Drug: Pembrolizumab	Case report	1	Ineffective	29215617
Iavarone et al[79]	Drug: Sorafenib	Multicenter retrospective study	28	Ineffective	31365177

mTOR: Mammalian target of rapamycin; PD-1: Programmed cell death protein 1; PD-L1: Programmed death ligand 1.