Liver transplantation with simultaneous splenectomy increases risk of cancer development and mortality in hepatocellular carcinoma patients

doi:10.4240/wjgs.v14.i9.930

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Sep 27, 2022 (publication date) through Jul 29, 2024

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Sep 27, 2022; 14(9): 930-939
Published online Sep 27, 2022. doi: 10.4240/wjgs.v14.i9.930

Table 3 Cox proportional hazard model for mortality

	Univariate		Multivariate
	Hazard ratio (95%CI)	P value	Hazard ratio (95%CI)	P value
Age	1.063 (0.994, 1.136)	0.075	-
Gender/male	1.424 (0.540, 3.757)	0.475	-
BMI	0.942 (0.834, 1.063)	0.333	-
HBV	4.386 (1.719, 11.193)	0.002^a	4.077 (1.001, 16.615)	0.050
HCV	2.853 (1.145, 7.114)	0.024^a	0.661 (0.166, 2.640)	0.558
Alcoholism	0.696 (0.161, 3.018)	0.629	-
Diabetes mellitus	1.640 (0.679, 3.958)	0.271	-
Hypertension	2.872 (1.142, 7.221)	0.025^a	2.813 (1.111, 7.123)	0.029^a
Tumor size	0.944 (0.679, 1.312)	0.732	-
Tumor number (2-3 vs 0-1)	1.911 (0.795, 4.596)	0.148	-
Lymphovascular invasion	2.054 (0.597, 7.062)	0.254	-
Splenectomy	3.656 (1.510, 8.848)	0.004^a	2.791 (1.081, 7.206)	0.034^a
PLT	1.000 (1.000, 1.000)	0.409	-
AFP	1.001 (1.000, 1.002)	0.081	-

^aP < 0.05.

CI: Confidence interval; BMI: Body mass index; HBV: Hepatitis B virus; HCV: Hepatitis C virus; GRWR: Graft-to-recipient weight ratio; INR: International normalized ratio; MELD: The Model for End-stage Liver Disease; AFP: α-fetoprotein.

Citation: Fan HL, Hsieh CB, Kuo SM, Chen TW. Liver transplantation with simultaneous splenectomy increases risk of cancer development and mortality in hepatocellular carcinoma patients. World J Gastrointest Surg 2022; 14(9): 930-939
URL: https://www.wjgnet.com/1948-9366/full/v14/i9/930.htm
DOI: https://dx.doi.org/10.4240/wjgs.v14.i9.930