Change of tumor-infiltrating lymphocyte of associating liver partition and portal vein ligation for staged hepatectomy for hepatocellular carcinoma

Table 9 Comparison of immunological data during conventional hepatectomy

Item	Preoperative	Conventional hepatectomy				F value	P value
		POD1	POD3	POD5	POD7
T lymphocyte count (cells/μL)	1194.7 ± 305.4	447.1 ± 240.9	808.8 ± 313.7	835.7 ± 323.7	1032.7 ± 323.6	123.342	0.000
Total T lymphocyte percentage (%)	71.2 ± 5.2	58.9 ± 14.5	65.9 ± 11.7	72.3 ± 9.1	72.8 ± 7.7	17.676	0.000
CD4+ T lymphocytes (cells/μL)	761.1 ± 146.6	244.1 ± 113.9	515.9 ± 155.1	520.7 ± 168.7	644.8 ± 149.1	198.675	0.000
CD8+T lymphocytes (cells/μL)	379.9 ± 119.0	147.9 ± 98.5	226.8 ± 104.5	253.0 ± 110.4	331.8 ± 120.9	106.219	0.000
Natural killer cells (%)	17.9 ± 4.7	25.8 ± 8.4	14.1 ± 3.0	12.9 ± 4.6	13.8 ± 3.8	12.893	0.000
IgA (g/L)	2.67 ± 1.49	2.23 ± 1.34	2.11 ± 1.32	2.44 ± 1.50	2.82 ± 1.60	19.117	0.000
IgG (g/L)	11.78 ± 5.58	8.14 ± 3.97	7.89 ± 3.98	8.09 ± 4.05	8.55 ± 3.95	35.249	0.000
IgM (g/L)	0.91 ± 0.39	0.54 ± 0.31	0.63 ± 0.26	0.66 ± 0.27	0.82 ± 0.30	24.051	0.000
Complement C1q (mg/L)	174.6 ± 51.3	142.8 ± 49.9	121.9 ± 46.9	125.1 ± 52.1	132.2 ± 47.0	39.750	0.000
Complement C3 (g/L)	1.11 ± 0.45	0.84 ± 0.41	0.74 ± 0.37	0.70 ± 0.36	0.73 ± 0.37	31.517	0.000
Complement C4 (g/L)	0.32 ± 0.13	0.24 ± 0.11	0.21 ± 0.11	0.22 ± 0.11	0.24 ± 0.12	37.071	0.000
Interleukin-6 (pg/mL)	16.3 ± 17.7	171.6 ± 119.2	73.3 ± 46.3	43.5 ± 28.8	44.1 ± 31.1	8.981	0.002
CD19 expression rate (%)	13.04 ± 2.21	9.93 ± 3.05	10.68 ± 3.40	12.81 ± 4.37	14.03 ± 3.62	11.115	0.000

ALPPS: Associating liver partition and portal vein ligation for staged hepatectomy; POD: Postoperative day; Ig: Immunoglobulin.