Change of tumor-infiltrating lymphocyte of associating liver partition and portal vein ligation for staged hepatectomy for hepatocellular carcinoma

Table 8 Comparison of immunological data during stage-II associating liver partition and portal vein ligation for staged hepatectomy

Item	Preoperative	Stage-II ALPPS				F value	P value
		POD1	POD3	POD5	POD7
T lymphocyte count (cells/μL)	1414.4 ± 634.0	455.9 ± 255.4	716.3 ± 311.3	796.3 ± 282.8	913.4 ± 387.1	17.626	0.000
Total T lymphocyte percentage (%)	67.8 ± 8.7	63.7 ± 9.2	72.3 ± 7.5	74.8 ± 6.4	73.6 ± 7.2	8.288	0.000
CD4+ T lymphocytes (cells/μL)	806.3 ± 428.2	246.4 ± 168.2	375.9 ± 170.1	493.9 ± 196.7	537.9 ± 231.3	7.925	0.003
CD8+ T lymphocytes (cells/μL)	438.2 ± 194.2	168.5 ± 89.4	290.3 ± 184.7	291.9 ± 159.0	356.1 ± 210.8	8.775	0.000
Natural killer cells (%)	16.5 ± 7.8	23.0 ± 7.1	12.7 ± 4.6	8.7 ± 4.8	10.2 ± 3.2	15.615	0.000
IgA (g/L)	3.11 ± 1.28	2.37 ± 1.88	2.31 ± 1.41	2.59 ± 1.30	3.40 ± 1.66	8.900	0.002
IgG (g/L)	15.11 ± 3.70	8.71 ± 2.10	8.11 ± 1.90	8.53 ± 1.66	9.68 ± 2.26	12.604	0.000
IgM (g/L)	1.27 ± 0.68	0.70 ± 0.37	0.67 ± 0.28	0.70 ± 0.36	0.83 ± 0.37	1.277	0.001
Complement C1q (mg/L)	194.5 ± 28.7	140.8 ± 33.8	111.1 ± 39.1	118.5 ± 41.3	124.2 ± 42.1	14.422	0.000
Complement C3 (g/L)	1.18 ± 0.19	0.72 ± 0.27	0.54 ± 0.20	0.58 ± 0.20	0.62 ± 0.18	24.345	0.000
Complement C4 (g/L)	0.40 ± 0.18	0.22 ± 0.16	0.15 ± 0.12	0.15 ± 0.14	0.17 ± 0.16	15.305	0.000
Interleukin-6 (pg/mL)	10.7 ± 17.0	210.3 ± 160.9	62.6 ± 27.6	37.1 ± 19.7	41.6 ± 61.3	12.206	0.000
CD19 expression rate (%)	10.5 ± 4.0	9.4 ± 5.1	10.2 ± 4.1	11.2 ± 5.8	11.0 ± 5.6	0.522	0.720

ALPPS: Associating liver partition and portal vein ligation for staged hepatectomy; POD: Postoperative day; Ig: Immunoglobulin.