Change of tumor-infiltrating lymphocyte of associating liver partition and portal vein ligation for staged hepatectomy for hepatocellular carcinoma

Table 7 Comparison of immunological data during stage-I associating liver partition and portal vein ligation for staged hepatectomy

Item	Preoperative	Stage-I ALPPS				F value	P value
		POD1	POD3	POD5	POD7
T lymphocyte count (cells/μL)	1331.5 ± 600.0	472.8 ± 289.9	682.0 ± 346.9	837.9 ± 383.6	1012.5 ± 444.2	10.095	0.001
Total T lymphocyte percentage (%)	67.8 ± 8.7	59.6 ± 8.5	68.4 ± 12.3	70.5 ± 11.7	68.9 ± 10.3	6.717	0.000
CD4+ T lymphocytes (cells/μL)	806.3 ± 428.2	241.1 ± 202.2	412.3 ± 224.7	520.1 ± 255.1	608.0 ± 266.1	9.049	0.002
CD8+ T lymphocyte (cells/μL)	438.2 ± 194.2	187.6 ± 96.6	238.9 ± 141.0	277.4 ± 143.5	361.2 ± 201.6	11.294	0.001
Natural killer cells (%)	16.5 ± 7.8	27.2 ± 8.6	10.8 ± 6.9	11.0 ± 3.7	11.2 ± 3.7	17.341	0.000
IgA (g/L)	3.11 ± 1.28	2.63 ± 1.64	1.87 ± 0.77	2.08 ± 0.79	2.69 ± 1.24	10.025	0.001
IgG (g/L)	15.11 ± 3.70	10.52 ± 2.89	8.70 ± 2.72	8.89 ± 2.69	9.82 ± 2.70	62.360	0.000
IgM (g/L)	1.27 ± 0.68	0.89 ± 0.40	0.71 ± 0.39	0.82 ± 0.38	1.08 ± 0.53	6.114	0.008
Complement C1q (mg/L)	194.5 ± 28.7	168.9 ± 44.2	140.4 ± 39.6	157.7 ± 45.9	159.17 ± 55.3	6.726	0.000
Complement C3 (g/L)	1.18 ± 0.19	0.87 ± 0.15	0.79 ± 0.19	0.87 ± 0.21	0.91 ± 0.26	44.808	0.000
Complement C4 (g/L)	0.40 ± 0.18	0.26 ± 0.12	0.23 ± 0.11	0.25 ± 0.12	0.28 ± 0.15	8.731	0.002
Interleukin-6 (g/L)	10.7 ± 17.0	177.4 ± 121.6	84.0 ± 62.3	52.6 ± 40.9	41.2 ± 35.1	7.877	0.003
CD19 expression rate (%)	10.5 ± 4.0	9.6 ± 5.62	12.1 ± 5.6	12.7 ± 5.2	13.3 ± 6.1	1.866	0.129

ALPPS: Associating liver partition and portal vein ligation for staged hepatectomy; POD: Postoperative day; Ig: Immunoglobulin.