Efficacy of staple line reinforcement by barbed suture for preventing anastomotic leakage in laparoscopic rectal cancer surgery

Table 4 Univariate and multivariate regression on anastomotic leakage-related factors (n = 319)

Variables	Univariate regression			Multivariate regression
	OR	95%CI	P value	OR	95%CI	P value
Male gender	1.189	0.523–2.705	0.680
Age ≥ 60 (yr)	2.123	0.824–5.473	0.119
BMI ≥ 25 (kg/m2)	1.115	0.448–2.775	0.814
Diabetic mellitus	2.604	1.060–6.394	0.037	1.662	0.588–4.669	0.338
Hypertension	1.039	0.374–2.888	0.941
Heart disease	2.050	0.652–6.441	0.219
COPD	1.739	0.372–8.124	0.482
Low tumor location < 5 (cm)	2.954	1.289–6.769	0.010	2.856	1.133–7.198	0.026
Tumor diameter ≥ 4 (cm)	3.010	1.313–6.901	0.009	2.994	1.185–7.563	0.020
T3-T4	1.135	0.410–3.142	0.807
Lymph node metastases	1.719	0.748–3.951	0.202
Previous laparotomy	1.884	0.602–5.890	0.276
Preoperative CEA ≥ 5 (ng/mL)	1.216	0.518-2.852	0.653
Preoperative serum albumin level < 35 (g/L)	1.690	0.673–4.244	0.264
Preoperative hemoglobin levels < 90 (g/L)	1.582	0.631–3.967	0.328
Preoperative serum CRP level, ≥ 10 (mg/L)	2.242	0.918–5.476	0.076
ASA score ≥ 3	1.244	0.499–3.102	0.639
Ligation of left colic artery	2.435	1.019–5.819	0.045	2.195	0.869–5.546	0.096
Operation time ≥ 150 (min)	2.437	1.059–5.613	0.036	1.837	0.750–4.495	0.183
Number of staple firings ≥ 3	2.577	0.893–7.434	0.080
Intraoperative transfusion	1.116	0.316–3.939	0.864
Intraoperative blood loss ≥ 60 (mL)	1.223	0.537–2.787	0.632
Reinforcing sutures	0.394	0.165–0.942	0.036	0.293	0.114–0.750	0.010
Postoperative intestinal obstruction	2.263	0.848–6.041	0.103

OR: Odds ratio; CI: Confidence interval; BMI: Body mass index; COPD: Chronic obstructive pulmonary disease; CEA: Carcinoma embryonic antigen; CPR: C-reactive protein; ASA: American society of anesthesiologists.