Impact of comorbid renal dysfunction in patients with hepatocellular carcinoma on long-term outcomes after curative resection

Table 4 Intraoperative parameters in the patients with severe and mild chronic kidney disease and without renal dysfunction

	CKD stage			P value
	Severe (EGFR < 30), n = 19	Mild (30 ≤ EGFR < 60), n = 109	Non-RD (EGFR ≥ 60), n = 672
Intraoperative variables
Operative time (min)	311.0 ± 112.0	331.0 ± 127.0	329.0 ± 108.0	0.52
Blood loss (mL)	389.0 ± 1254.1	380.0 ± 3464.9	425.0 ± 1577.3	0.64
Procedure of resection
Anatomical resection	13 (68.4)	86 (78.9)	498 (74.1)	0.46
Nonanatomical resection	6 (31.6)	23 (21.1)	174 (25.9)	-
Resected liver weight (g)	365.0 ± 388.5	222.0 ± 471.3	252.0 ± 630.0	0.24
Curability
A + B	19 (100.0)	98 (89.9)	563 (83.8)	< 0.05
C	0 (0.0)	11 (10.1)	109 (16.2)	-
Tumor characteristics
Tumor size (cm)	5.8 ± 4.0	4.5 ± 3.8	4.4 ± 4.6	0.41
Tumor number	1.0 ± 2.1	1.0 ± 1.6	1.0 ± 2.8	0.44
pStage1
I	1 (5.3)	7 (6.4)	53 (7.9)	0.45
II	8 (42.1)	54 (49.5)	272 (40.5)	-
III	7 (36.8)	33 (30.3)	207 (30.8)	-
IV	3 (15.8)	15 (13.8)	140 (20.8)	-
Pathological grade
Well	2 (10.5)	22 (20.2)	95 (14.1)	0.84
Mod-por	17 (89.5)	87 (79.8)	577 (85.9)	-
Vascular invasion1
Yes	2 (10.5)	9 (8.3)	145 (21.6)	< 0.01
No	17 (89.5)	100 (91.7)	527 (78.4)	-
Liver fibrosis score2
0-1	7 (36.8)	37 (34.0)	143 (21.2)	< 0.001
2	8 (42.1)	35 (32.1)	172 (25.6)	-
3	3 (15.8)	19 (17.4)	149 (22.2)	-
4	1 (5.3)	18 (16.5)	208 (31.0)	-

¹Liver Cancer Study Group of Japan, 6^th edition.

²Liver fibrosis was graded and staged according to the New Inuyama classification system as follows: F1 (periportal expansion), F2 (porto-portal septa), F3 (porto-central linkage or bridging fibrosis), and F4 (cirrhosis).

P values were determined by the χ² test or by the Kruskal-Wallis U test. The liver fibrosis score was assessed by expert pathologists using a noncancerous lesion from the resected specimen. RD: Renal dysfunction; CKD: Chronic kidney disease; EGFR: Estimated glomerular filtration rate.