Impact of comorbid renal dysfunction in patients with hepatocellular carcinoma on long-term outcomes after curative resection

Table 3 Intraoperative parameters in the patients with and without renal dysfunction

	CKD stage		P value
	RD (EGFR < 60), n = 128	Non-RD (EGFR ≥ 60), n = 672
Intraoperative variables
Operative time (min)	323.0 ± 125.0	329.0 ± 108.0	0.70
Blood loss (mL)	380.0 ± 3230.1	425.0 ± 1577.3	0.42
Procedure of resection
Anatomical resection	99 (77.3)	498 (74.1)	0.44
Nonanatomical resection	29 (22.7)	174 (25.9)	-
Resected liver weight (g)	239.0 ± 459.3	252.0 ± 630.0	0.57
Curability
A + B	117 (91.4)	563 (83.8)	< 0.05
C	11 (8.6)	109 (16.2)	-
Tumor characteristics
Tumor size (cm)	4.5 ± 3.9	4.4 ± 4.6	0.85
Tumor number	1.0 ± 1.7	1.0 ± 2.8	0.55
PStage1
I	8 (6.3)	53 (7.9)	0.11
II	62 (48.4)	272 (40.5)	-
III	40 (31.3)	207 (30.8)	-
IV	18 (14.1)	140 (20.8)	-
Pathological grade
Well	24 (18.7)	95 (14.1)	0.29
Mod-por	104 (81.3)	577 (85.9)	-
Vascular invasion1
Yes	11 (8.6)	145 (21.6)	< 0.001
No	117 (91.4)	527 (78.4)	-
Liver fibrosis score2
0-1	44 (34.4)	143 (21.2)	< 0.0001
2	43 (33.6)	172 (25.6)	-
3	22 (17.2)	149 (22.2)	-
4	19 (14.8)	208 (31.0)	-

¹Liver Cancer Study Group of Japan, 6^th edition.

²Liver fibrosis was graded and staged according to the New Inuyama classification system as follows: F1 (periportal expansion), F2 (porto-portal septa), F3 (porto-central linkage or bridging fibrosis), and F4 (cirrhosis).

P values were determined by the χ² test or the Mann-Whitney U test. The liver fibrosis score was assessed by expert pathologists using a noncancerous lesion from the resected specimen. RD: Renal dysfunction; CKD: Chronic kidney disease; EGFR: Estimated glomerular filtration rate.