Impact of comorbid renal dysfunction in patients with hepatocellular carcinoma on long-term outcomes after curative resection

Table 2 Characteristics of the patients with severe and mild chronic kidney disease and without renal dysfunction

	CKD stage			P value
	Severe (EGFR < 30), n = 19	Mild (30 ≤ EGFR < 60), n = 109	Non-RD (EGFR ≥ 60), n = 672
Age (yr)	73.0 ± 8.9	69.0 ± 8.6	63.0 ± 10.4	< 0.0001
Sex
Male	13 (68.4)	98 (89.9)	549 (81.7)	< 0.05
Female	6 (31.6)	11 (10.1)	123 (18.3)	-
Etiology
HBV	5 (26.3)	24 (22.0)	263 (39.1)	< 0.01
HCV	8 (42.1)	33 (30.3)	218 (32.4)	0.59
NBNC	6 (31.6)	52 (47.7)	191 (28.5)	< 0.001
Child-Pugh grade
A	19 (100.0)	105 (96.3)	649 (96.6)	0.71
B	0 (0.0)	4 (3.7)	23 (3.4)	-
Laboratory data
Plt (×104/μL)	14.5 ± 5.2	16.3 ± 6.4	15.5 ± 7.3	0.76
PT (%)	94.9 ± 10.1	95.2 ± 14.3	91.7 ± 14.7	0.35
Alb (g/dL)	3.8 ± 0.3	4.1 ± 0.4	4.1 ± 0.4	< 0.01
T-bil (mg/dL)	0.4 ± 0.2	0.7 ± 0.3	0.8 ± 0.4	< 0.001
AST (IU/L)	27.0 ± 17.4	38.0 ± 32.5	43.0 ± 43.4	0.07
ALT (IU/L)	21.0 ± 19.0	34.0 ± 30.9	40.0 ± 36.1	< 0.05
ChE (IU/L)	181.0 ± 68.1	249.0 ± 90.0	245.0 ± 81.3	< 0.01
ICG15R (%)	10.5 ± 6.2	15.3 ± 7.3	13.6 ± 10.6	0.18
HbA1c (%)	5.5 ± 1.0	5.9 ± 1.1	5.3 ± 1.1	< 0.05
BUN (mg/dL)	38.0 ± 15.8	19.0 ± 5.2	14.0 ± 4.0	< 0.0001
Cr (mg/dL)	2.4 ± 3.2	1.0 ± 0.2	0.7 ± 0.1	< 0.0001
AFP (ng/mL)	51.5 (2.1-164321.4)	6.5 (1.4-37525.5)	19.9 (0-5986980)	0.61
AFP-L3 (%)	21.7 ± 30.6	0.0 ± 21.6	3.1 ± 24.4	< 0.05
PIVKA-II (mAU/mL)	1309.0 (10-167600)	105.0 (0-436410)	136.0 (0-664680)	0.93

P values were determined by the χ² test or by the Kruskal-Wallis U test. RD: Renal dysfunction; HBV: Hepatitis B virus; HCV: Hepatitis C virus; NBNC: Non-hepatitis B virus or hepatitis C virus; Plt: Platelet count; PT: Prothrombin time; Alb: Serum albumin; T-bil: Total bilirubin; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ChE: Choline esterase; ICGR15: Indocyanine green rate at 15 min; HbA1c: Hemoglobin A1c; BUN: Blood urea nitrogen; Cr: Creatinine; AFP: Alpha-fetoprotein; AFP-L3: Alpha-fetoprotein isoform, lectin affinity; PIVKA-II: Protein-induced vitamin K absence-II; CKD: Chronic kidney disease; EGFR: Estimated glomerular filtration rate.