Impact of comorbid renal dysfunction in patients with hepatocellular carcinoma on long-term outcomes after curative resection

Table 1 Characteristics of the patients with and without renal dysfunction

	RD (EGFR < 60), n = 128	Non-RD (EGFR ≥ 60), n = 672	P value
Age (yr)	69.5 ± 8.6	63.0 ± 10.4	< 0.0001
Sex
Male	111 (86.7)	549 (81.7)	0.17
Female	17 (13.3)	123 (18.3)	-
Etiology
HBV	29 (22.7)	263 (39.1)	< 0.001
HCV	41 (32.0)	218 (32.4)	0.93
NBNC	58 (45.3)	191 (28.5)	< 0.001
Child-Pugh grade
A	124 (96.9)	649 (96.6)	0.86
B	4 (3.1)	23 (3.4)	-
Laboratory data
Plt (×104/μL)	16.2 ± 6.2	15.5 ± 7.3	0.26
PT (%)	94.9 ± 13.7		0.08
Alb (g/dL)	4.0 ± 0.4	4.1 ± 0.4	0.32
T-bil (mg/dL)	0.7 ± 0.3	0.8 ± 0.4	< 0.001
AST (IU/L)	35.5 ± 31.2	43.0 ± 43.4	< 0.05
ALT (IU/L)	31.5 ± 30.0	40.0 ± 36.1	< 0.01
ChE (IU/L)	238.0 ± 89.8	245.0 ± 81.3	0.92
ICG15R (%)	14.4 ± 7.3	13.6 ± 10.6	0.61
HbA1c (%)	5.7 ± 1.1	5.3 ± 1.1	< 0.05
BUN (mg/dL)	20.0 ± 10.8	14.0 ± 4.0	< 0.0001
Cr (mg/dL)	1.1 ± 1.6	0.7 ± 0.1	< 0.0001
AFP (ng/mL)	10.3 (1.4-164321.4)	19.9 (0-5986980)	< 0.01
AFP-L3 (%)	0.0 ± 23.8	3.1 ± 24.4	< 0.05
PIVKA-II (mAU/mL)	11385.0 (0-436410)	136.0 (0-664680)	0.68

P values were determined by the χ² test or the Mann-Whitney U test. RD: Renal dysfunction; HBV: Hepatitis B virus; HCV: Hepatitis C virus; NBNC: Non-hepatitis B virus or hepatitis C virus; Plt: Platelet count; PT: Prothrombin time; Alb: Serum albumin; T-bil: Total bilirubin; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ChE: Choline esterase; ICGR15: Indocyanine green rate at 15 min; HbA1c: Hemoglobin A1c; BUN: Blood urea nitrogen; Cr: Creatinine; AFP: Alpha-fetoprotein; AFP-L3: Alpha-fetoprotein isoform, lectin affinity; PIVKA-II: Protein-induced vitamin K absence-II; EGFR: Estimated glomerular filtration rate.