Prognostic significance of the preoperative hemoglobin to albumin ratio for the short-term survival of gastric cancer patients

Table 1 Prognostic analysis of clinical characteristics in patients with gastric cancer

Clinical variable	n	Univariate analysis		Multivariate analysis
	312	HR (95%CI)	P value	HR (95%CI)	P value
Age (yr)	62 (54-68)	1.046 (1.015-1.077)	0.003	1.049(1.017-1.081)	0.002
Sex (male/female)	225/87	0.715 (0.400-1.280)	0.259
BMI (kg/m2)	21.55 (19.53-23.55)	0.983 (0.911-1.062)	0.670
Smoking (yes/no)	64/248	0.442 (0.189-1.034)	0.060
Drinking (yes/no)	49/263	1.316 (0.641-2.701)	0.454
CEA (ng/mL)	2.94 (1.85-5.29)	1.006 (1.003-1.009)	0.000
CA19-9 (U/mL)	13.26 (7.36-23.70)	1.001 (1.000-1.002)	0.003
CA125 (U/mL)	8.50 (5.90-13.80)	1.008 (1.000-1.016)	0.049
CA72-4 (IU/mL)	1.81 (1.17-4.46)	1.004 (0.990-1.018)	0.57
HAR	3.18 (2.68-3.44)	0.425 (0.278-0.650)	0.000	0.466 (0.301-0.720)	0.001
PHR	1.86 (1.40-2.58)	1.371 (1.194-1.575)	0.000
PLR	157.74 (114.06-211.23)	1.003 (1.001-1.006)	0.004
PAR	5.75 (4.51-7.48)	1.184 (1.088-1.288)	0.000
FLR	2.05 (1.49-2.89)	1.171 (1.018-1.347)	0.028
AFR	13.16 (10.36-16.85)	0.970 (0.912-1.033)	0.344
HFR	42.52 ± 17.83	0.974 (0.955-0.993)	0.007
PFR	77.41 (57.84-101.46)	1.005 (0.998-1.012)	0.135
NLR	2.47 (1.76-3.59)	1.100 (0.974-1.242)	0.124
ALR	26.25 (22.16-35.08)	1.008 (0.986-1.030)	0.489
Tumor size (cm)	4.0 (2.5-5.5)	1.167 (1.079-1.262)	0.000
Vascular infiltration (present/absent)	168/144	3.230 (1.695-6.153)	0.000
Nerve infiltration (present/absent)	149/163	2.974 (1.651-5.359)	0.000
Histological grade (G1/G2/G3)	6/120/186	0.920 (0.553-1.530)	0.748
Stage (Ⅰ/Ⅱ/Ⅲ)	88/75/149	4.154 (2.291-7.531)	0.000	4.112 (2.225-7.602)	0.000
Survival status (death/survival)	53/259
Follow-up time (d)	531 (440-691)

BMI: Body mass index; PHR: Platelet to hemoglobin ratio; PLR: Platelet to lymphocyte ratio; PAR: Platelet to albumin ratio; FLR: Fibrinogen to lymphocyte ratio; AFR: Albumin to fibrinogen ratio; HFR: Hemoglobin to fibrinogen ratio; PFR: Platelet to fibrinogen ratio; NLR: Neutrophil to lymphocyte ratio; ALR: Albumin to lymphocyte ratio. HR: Hazard ratio; CI: Confidence interval; HAR: Hemoglobin to albumin ratio.