Transjugular intrahepatic portosystemic shunt with radioactive seed strand for main portal vein tumor thrombosis with cirrhotic portal hypertension

doi:10.4240/wjgs.v14.i6.567

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Jun 27, 2022 (publication date) through Aug 24, 2024

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Jun 27, 2022; 14(6): 567-579
Published online Jun 27, 2022. doi: 10.4240/wjgs.v14.i6.567

Table 5 Correlative factors for survival in univariate and multivariate analyses

Variable	Univariate analysis			Multivariate analysis
Variable	HR	95%CI	P value	HR	95%CI	P value
Gender (female/male)	1.237	0.650-2.355	0.518
Age (years)	1.039	1.011-1.068	0.006
BMI	0.781	0.701-0.871	< 0.001	0.861	0.768-0.965	0.010
EGV degree (mild/moderate/severe)	1.130	0.796-1.605	0.493
Ascites degree (no/mild/moderate-severe)	1.055	0.760-1.464	0.748
Preoperative HVPG (mmHg)	1.006	0.979-1.034	0.668
Child-Pugh grade			< 0.001
A/B	1.856	1.068-3.225	0.028	2.243	1.270-3.961	0.005
A/C	4.999	2.099-11.907	< 0.001	7.308	2.898-18.425	< 0.001
Intrahepatic HCC morphology (unifocal/multifocal)	0.909	0.570-1.447	0.687
Sum of longest viable tumor diameters (cm)	1.070	0.988-1.158	0.097
BCLC stage (C/D)	3.216	1.509-6.851	0.002
cTNM stage (IIIB/IVA/IVB)	3.269	2.228-4.795	< 0.001	2.745	1.726-4.366	< 0.001
PLT (10⁹/L)	1.000	0.997-1.003	0.917
PT (s)	1.006	0.959-1.056	0.802
ALT (U/L)	1.004	0.994-1.013	0.465
AST (U/L)	1.003	0.998-1.008	0.173
TBil (μmol/L)	1.022	1.008-1.035	0.001
Albumin (g/L)	0.929	0.886-0.974	0.002
Log₁₀(AFP) (ng/mL)	1.341	1.097-1.639	0.004
Combined RFA (no/yes)	0.885	0.552-1.419	0.612
Combined targeted therapy (no/yes)	0.994	0.627-1.574	0.978
Reduction of PVP (mmHg)	1.025	0.983-1.069	0.247
PVTT response (nonresponse/response)	0.302	0.176-0.516	< 0.001	0.472	0.259-0.859	0.014
Post-TIPS HE (no/yes)	0.864	0.482-1.551	0.625
Shunt stenosis (no/yes)	1.039	0.650-1.662	0.873
Recurrence of CPH (no/yes)	1.122	0.694-1.814	0.639

BMI: Body mass index; EGV: Esophagogastric varices; HVPG: Hepatic venous pressure gradient; HCC: Hepatocellular carcinoma; PLT: Platelet; PT: Prothrombin time; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TBil: Total bilirubin; AFP: Alpha-fetoprotein; RFA: Radiofrequency ablation; PVP: Portal vein pressure; PVTT: Portal vein tumor thrombosis; TIPS: Transjugular intrahepatic portosystemic shunt; HE: Hepatic encephalopathy; CPH: Cirrhotic portal hypertension.

Citation: Yan XH, Yue ZD, Zhao HW, Wang L, Fan ZH, Wu YF, Meng MM, Zhang K, Jiang L, Ding HG, Zhang YN, Yang YP, Liu FQ. Transjugular intrahepatic portosystemic shunt with radioactive seed strand for main portal vein tumor thrombosis with cirrhotic portal hypertension. World J Gastrointest Surg 2022; 14(6): 567-579
URL: https://www.wjgnet.com/1948-9366/full/v14/i6/567.htm
DOI: https://dx.doi.org/10.4240/wjgs.v14.i6.567